Week 6 kicks off with a snoozer, as Daniel Jones leads the injury-riddled Giants into Foxborough to face the undefeated Patriots. The rest of the weekend, however, looks stacked.

I'd like to thank Vegas for making the No. 1 team in DVOA three-point underdogs this week, making our Upset Watch choice fairly easy. The Rams have more rest and the 49ers have more injuries, but it's still easy to see a path to a San Francisco victory.

This week: Washington's mess of a franchise, running backs talk usage and money, weird and not-so-weird animals, and playoff baseball.

The biggest game of the week sees Oklahoma face Sam Ehlinger and Texas in the Red River Rivalry. Elsewhere, Notre Dame visits USC, and Florida squares off against LSU in a battle of unbeatens.

Over at ESPN+, Bryan Knowles takes a closer look at our numbers on the San Francisco 49ers. Why are they so high in DVOA right now, and are they a legit Super Bowl contender this season?

Baltimore's offensive tackles played very well in the win over Pittsburgh. The interior linemen? Not so much.

Temperatures are dropping, and the winds are picking up. That's bad news for a lot of quarterbacks -- but not necessarily for Aaron Rodgers.

The Thursday edition of the Football Outsiders Fantasy Podcast will delve into the best and worst matchups for Week 6, which include several Cardinals, Aaron Rodgers, Chris Thompson, and Cooper Kupp on the good and several Saints, Jordan Howard, and Julio Jones on the bad side of the draw. (Click for audio link.)

We're going big on the NFC in this week's Off The Charts podcast, with previews of the Lions at Packers, Eagles at Vikings, and 49ers at Rams games. Plus, injury updates! (Click for audio link.)

Cleveland's franchise quarterback has stumbled out of the gates in his second season. What are the holes in his game, and what can Freddie Kitchens and the coaching staff do to manage them?