Week 7 kicks off tonight with an AFC West matchup as the suddenly struggling Chiefs, losers of two in a row, travel to Denver to take on the Broncos. Big Sunday games include Houston (4-2) at Indianapolis (3-2), Minnesota (4-2) at Detroit (2-2-1), and Baltimore (4-2) at Seattle (5-1).

This week: new faces in new places; the newly rich deal with new money; new stars need new nicknames; old friends become new enemies; and some teams are just always terrible.

Our Upset Watch column is 5-1 so far this season, and this week's pick is for the Eagles in the big Sunday night NFC East showdown. Injuries will play a major role in this game, not only in the players missing the game but also in the players who will not be at 100%.

The biggest game of the week sees Shea Patterson and Michigan visit to play Penn State. Other big conference games this weekend include Florida-South Carolina, Oregon-Washington, and Baylor-Oklahoma State.

The Jets offensive line did a great job of helping out quarterback Sam Darnold in his return to the lineup -- and Darnold returned the favor, covering up the mistakes his line made as well.

Week 7 is missing some of the premiere options at running back and wide receiver with Christian McCaffrey, Nick Chubb, Mike Evans, Chris Godwin, and Odell Beckham on bye. That makes defensive matchups key in another week with mild temperatures and no wind or rain forecasted.

The Thursday edition of the Football Outsiders Fantasy Podcast will delve into the best matchups for Week 7 including Jared Goff, Phillip Lindsay, Michael Gallup, and T.Y. Hilton and worst matchups including Deshaun Watson, Latavius Murray, and Tyreek Hill. (Click for audio link.)

Mike Tanier comes on this week's Off The Charts podcast to discuss the current state of the Running Backs Don't Matter theory. Then we preview three big weekend games: Eagles-Cowboys, Texans-Colts, and Vikings-Lions. (Click for audio link.)

How do you protect your franchise quarterback when you can't rely on your offensive line? You spread the field with empty formations and let said franchise quarterback do what he does best.

Was South Carolina's 20-17 victory over Georgia the biggest upset of the college football season? Not quite -- especially not with what we know about both teams now.