It has been a long, long time since a quarterback has given up as many sacks and interceptions as Jameis Winston did against Tampa Bay. Plus, the best passers, runners, and receivers of Week 6.

The Browns and Chiefs produced more yards per play than their opponents, the Seahawks and Texans, but that didn't secure them wins in Week 6.

Three playoff contenders lose starters for a significant period in another rough week of NFL action.

South Carolina knocked off an offense-less third-ranked Georgia, while Oklahoma and LSU continued to dominate, even in their toughest matchups to date.

Is Kyle Allen a legitimate starting quarterback? Just how good is the 49ers defense? What exactly is the difference between Marcus Mariota and Ryan Tannehill? Your Audibles crew discusses the Week 6 action.

Week 6 kicks off with a snoozer, as Daniel Jones leads the injury-riddled Giants into Foxborough to face the undefeated Patriots. The rest of the weekend, however, looks stacked.

I'd like to thank Vegas for making the No. 1 team in DVOA three-point underdogs this week, making our Upset Watch choice fairly easy. The Rams have more rest and the 49ers have more injuries, but it's still easy to see a path to a San Francisco victory.

This week: Washington's mess of a franchise, running backs talk usage and money, weird and not-so-weird animals, and playoff baseball.

The biggest game of the week sees Oklahoma face Sam Ehlinger and Texas in the Red River Rivalry. Elsewhere, Notre Dame visits USC, and Florida squares off against LSU in a battle of unbeatens.

Over at ESPN+, Bryan Knowles takes a closer look at our numbers on the San Francisco 49ers. Why are they so high in DVOA right now, and are they a legit Super Bowl contender this season?