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ESPN Upset Watch: Panthers-49ers

Christian McCaffrey
Photo: USA Today Sports Images

Here's something you won't often hear from me: the secret to Carolina upsetting the undefeated 49ers may be to run the ball and stop the run. The latter has been tough for them this year. But if they force Jimmy Garoppolo into long down-and-distance situations, the underrated Panthers defense could pull off a big upset.

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